POS0718 CLINICAL CHARACTERISTICS ASSOCIATED WITH GLANDULAR INVOLVEMENT EVALUATED BY SALIVARY GLAND ULTRASONOGRAPHY IN SJÖGREN’S SYNDROME

Background: Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by periductal lymphocytic infiltration of the salivary and lacrimal glands, which results in reduced secretory functions oral ocular dryness (1). In addition, patients often have extraglandular manifestations, such as interstitial pneumonia nephritis, appearance autoantibodies anti-Ro/SS-A La/SS-B antibodies. Salivary gland ultrasonography (SGUS) typically used to evaluate findings glands; thus, we can severity disorders due SS using SGUS real time (2). Objectives: To identify clinical indices, including activity, associated with glandular involvement evaluated SS. Methods: We enrolled (n=115) non-SS sicca subjects (n=90) who visited Nagasaki University Hospital between 1995 2019. The patients’ classifications were based on 2002 American–European Consensus Group (AECG) classification criteria (3). exhibited symptoms but did not fulfill AECG criteria. indices age, sex, focus score (FS), symptoms, Saxon test results, Schirmer’s anti-SS-A/Ro antibody positivity, anti-SS-B/La anti-centromere (ACA) serum immunoglobulin G levels, European League Against Rheumatism activity index examined. (US) was calculated imaging (hypoechoic area, hyperechoic band, irregular border) (4). Results: US significantly higher than that subjects. found significant correlations FS Multivariate analysis revealed FS, ACA positivity variables independently These same primary patient group (n=96). Patients had scores compared those negativity, whereas high. greater bands negativity. Conclusion: This study indicated reflected sialadenitis SS, suggest might show specific changes fibrosis, only (5). References: [1]Ramos-Casals M, Tzioufas AG, Font J. Primary Sjogren’s syndrome: new therapeutic concepts. Ann Rheum Dis. 2005;64(3):347-54. [2]van Ginkel MS, Glaudemans A, van der Vegt B, Mossel E, Kroese FGM, Bootsma H, et al. Imaging Syndrome. J Clin Med. 2020;9(8). [3]Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Classification for revised version proposed American-European Group. 2002;61(6):554-8. [4]Takagi Y, Nakamura Sumi Shimizu T, Hirai Horai Combined system ACR/EULAR ultrasonographic improving diagnosis syndrome. PLoS One. 2018;13(4):e0195113. [5]Nakamura Kawakami Hayashi Iwamoto N, Okada Tamai Anti-centromere antibody-seropositive differs from conventional subgroup pathological study. BMC Musculoskelet Disord. 2010;11:140. Disclosure Interests: None declared